Sickle cell disorders are a group of illnesses which affect red blood cells, impairing their ability to carry oxygen and increasing the risk of a number of health problems, including anemia, bone and organ damage, infection, chronic pain, and shortened life expectancy.

September is National Sickle Cell Awareness Month in the United States - an event recognized by the US Congress to raise awareness about the condition around the world. Cochrane has a number of systematic reviews assessing the available evidence for management and treatment of symptoms related to sickle cell disorders:

Vitamin D supplementation for sickle cell disease

Magnesium for treating sickle cell disease

Folate supplementation in people with sickle cell disease

Phytomedicines (medicines derived from plants) for sickle cell disease